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刘娜

一、教育经历:

2003/9 - 2008/7,中国医科学院京协和医科大学,细胞生物学,博士

1996/9 - 2001/7,中国药科大学,药理学,学士

 

二、科研与学术工作经历:

2021/1 - 现在,   南开大学,医学院,研究员

2016/7 - 2020/12,南开大学,医学院,副研究员

2012/12016/07,南开大学,生命科学学院,副研究员

2013/8 - 2014/08,耶鲁大学,遗传系,访问学者

2008/7 - 2011/12,南开大学,生命科学学院,讲师

 

三、研究方向:干细胞生物学

(一)研究领域

1、胚胎干细胞全能性维持分子机制

2、干细胞抵御机体衰老策略及机制

3、干细胞分化调控及体内示踪

(二)科研项目

1.  国家自然科学基金:32070860Dppa3在胚胎干细胞多能性维持及DNA甲基化调控中的作用机制,2021.1-2024.12 主持

2.  国家自然科学基金:31771636Lin28a调控ES细胞naïve-primed状态转变机制研究,2018.1-2021.12 主持

3.  国家自然科学基金:31000651,印迹基因H19表达调控与孤雌胚胎干细胞多能性关系研究,2011.1-2013.12,主持       

4.  天津市自然科学基金重点项目:14JCZDJC35200,先天性角化不良发病机制探究, 2014.3-2017.4,主持

5.  天津市自然科学基金面上项目:18JCYBJC24400,2019.01-2019.12,主持

7.  中央高校基本科研业务费专项资金:印迹基因H19表达调控与孤雌胚胎干细胞多能性关系研究, 2010.6-2012.5,主持

8.  中国人民解放军总医院肾脏疾病国家重点实验室开放课题:KF-19-07, MSC联合ES-EV在急性肾损伤治疗中的作用, 2020.1-2021.12,主持

, Na Liu*. , Na Liu*, and *. Embryonic stem cell preconditioned microenvironment suppresses tumorigenic properties in breast cancer. Stem Cell Res Ther. 2016, 7(1):95 Corresponding Author

[16]  Liu N, Lu M, Feng XM, Ma FX, Fang ZH, Tian XM, Ren Q, Zhang L, Liu B, Huang PP, Liu L, Han ZC. Exogenous Nanog alleviates but is insufficient to reverse embryonic stem cells differentiation induced by PI3K signaling inhibition.J Cell Biochem. 2009, 106(6):1041-1047.First Author

[17]  Liu N, Feng X, Fang Z, Ma F, Lu S, Lu M, Han Z. Identification of Genes Regulated by Nanog Which Is Involved In ES Cells Pluripotency and Early Differentiation. J Cell Biochem.2008, 104(6):2348-2362.First Author

[18]  Liu N, Lu M, Tian X, Han Z.Molecular mechanisms involved in self-renewal and pluripotency of embryonic stem cells. J Cell Physiol. 2007, 211(2):279-286.First Author

[19]  Liu N, Lu M. The signal transduction pathways and molecules for ES cells self-renewal, Chinese Science Bulletin. 2005, 50(8):721-726.First Author

[20]  Na Liu,  Xin Qi, Zhibo Han, Lu Liang, Deling Kong, Zhongchao Han, Shihua Zhao, Zuo-Xiang He, and Zongjin Li*.  Sci Rep. 2016, 6:28739. First Author

[21]  Chen Wang, Guoyun Li, Kaige Cui, Zihan Chai, Ziyu Huang, Yue Liu, Shang Chen, Haoyan Huang, Kaiyue Zhang, Zhibo Han, Yuhao Li, Guangli Yu, Zhong-Chao Han, Na Liu*, Zongjin Li*. Sulfated glycosaminoglycans in decellularized placenta matrix as critical regulators for cutaneous wound healing. Acta Biomater. 2021 Mar 1;122:199-210. Corresponding Author

[22]  Liang L, Yue Z, Du W, Li Y, Tao H, Wang D, Wang R, Huang Z, He N, Xie X, Han Z, Liu N*, Li Z*. Molecular Imaging of Inducible VEGF Expression and Tumor Progression in a Breast Cancer Model. Cell Physiol Biochem. 2017 May 25;42(1):407-415. Corresponding Author

[23]  Huifang Li, Haoyan Huang, Xiaoniao Chen, Shang Chen, Lu Yu, Chen Wang, Yue Liu, Kaiyue Zhang, Lingling Wu, Zhong-Chao Han, Na Liu*, Jie Wu*, Zongjin Li*. The delivery of hsa-miR-11401 by extracellular vesicles can relieve doxorubicin-induced mesenchymal stem cell apoptosis. Stem Cell Res Ther. 2021 Jan 22;12(1):77. Corresponding Author Biomaterials. 2017 Dec 16;158:34-43.

[28]  Liu Y, Song B, Wei Y, Chen F, Chi Y, Fan H, Liu N, Li Z, Han Z, Ma F.&nbsp;Cytotherapy. 2017 Dec 18. pii: S1465-3249(17)30733-8.

[29]  Wang R, Zhang K, Tao H, Du W, Wang D, Huang Z, Zhou M, Xu Y, Wang Y, Liu N, Wang H, Li Z. Molecular Imaging of Tumor Angiogenesis and Therapeutic Effects with Dual Bioluminescence. Curr Pharm Biotechnol.  2017;18(5):422-428.

[30]  Du W, Zhang K, Zhang S, Wang R, Nie Y, Tao H, Han Z, Liang L, Wang D, Liu J, Liu N, Han Z, Kong D, Zhao Q, Li Z. Enhanced proangiogenic potential of mesenchymal stem cell-derived exosomes stimulated by a nitric oxide releasing polymer. Biomaterials. 2017 Jul;133:70-81.

[31]  Liu K, Mao J, Song L, Fan A, Zhang S, Wang J, Fan N, Liu N, Ye X, Fu H, Zhou Z, Wang Y, Wei H, Liu Z, Li Z, Lai L, Wang X, Liu L. DNA repair and replication links to pluripotency and differentiation capacity of pig iPS cells. PLoS One. 2017 Mar 2;12(3):e0173047.

[32]  Song X, Liu D, Cui J, Zhou M, Wang H, Liu N, Qi X, Li Z. Identification of Stem-Like Cells in Atrial Myxoma by Markers CD44, CD19, and CD45. Stem Cells Int. 2016;2016:2059584.

[33]  Guowei Feng, Jimin Zhang, Yang Li, Yan Nie, Dashuai Zhu, Ran Wang, Jianfeng Liu, Jie Gao, Na Liu, Ningning He, Wei Du, Hongyan Tao, Yongzhe Che, Yong Xu, Deling Kong, Qiang Zhao, and&nbsp;Zongjin Li*.  J Am Soc Nephrol. 2016, 27(8):2357-69. 

[34]  Wang D, Meng Q, Huo L, Yang M, Wang L, Chen X, Wang J, Li Z, Ye X, Liu N, Li Q, Dai Z, Ouyang H, Li N, Zhou J, Chen L, Liu L. Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice. Protein Cell. 2015, 6(2):152-6.

 Cell Res. 2013, 23(1):162-6.

 Stem Cells. 2013 31(11):2538-50.

Cell Research. 2012; 22(4): 757-768.

J Cell Mol Med. 2009 13(8B):2039-52.

, , ,  , .  Composition and Function of the Extracellular Matrix in the Human Body. INTECH, 2016

[48]  Yan Zhang, Zongjin Li, and Na Liu*The Stemness of Perinatal Stem CellPerinatal Stem CellsISBN 978-981-13-2702-5, ISBN 978-981-13-2703-2 (eBook)Springer Nature Singapore Pte Ltd. 2019

 

六、讲授课程
1.细胞生物学 (本科生,主讲)
2
.干细胞与再生医学 (硕士研究生,主讲)

3. 干细与再生医前沿 (博士研究生)

 

七、荣誉和奖励
12012年南开大学教学成果奖 二等奖

22016年南开大青年教师教学基本功竞赛 二等奖

32016年天津市青年教师教学基本功竞赛 三等奖


八、联系方式
1. 通讯地址:天津市卫津路94号南开大学医学院304
2 E-mailliuna@blossomsandbells.com